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. 2022 Dec 6;41:334. doi: 10.1186/s13046-022-02538-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — YTHDF3 promotes glycolysis metabolism of HCC cells.a The blood glucose level between YTHDF3 low and high-expression HCC patients (upper). The blood glucose level between Ythdf3^+/+ and Ythdf3^−/− mice (lower). b. The relative ratio of pyruvate and lactate level in liver cancer tissues and plasma between Ythdf3^+/+ and Ythdf3^−/− mice. c The relative ratio of glucose uptake, pyruvate, lactate and ATP production after YTHDF3 knockdown in Huh7 and SNU449 cells. d ECAR and OCR were examined after YTHDF3 knockdown in Huh7 and SNU449 cells. e The relative ratio of glucose uptake, pyruvate, lactate and ATP production after YTHDF3 overexpression in Sk-Hep-1 and HepG2 cells. f ECAR and OCR were examined after YTHDF3 overexpression in Sk-Hep-1 and HepG2 cells. Data are presented as mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001). Abbreviations: ECAR, extracellular acidification rate; OCR, cellular oxygen consumption rate