Table 4.
Biochemical and hormonal parameters were obtained for the Reproductive, Premenopausal and Postmenopausal groups
| Groups: Median (1º—3º Quartile) or M ± SD | p-value | |||||
|---|---|---|---|---|---|---|
| Biochemical and Hormonals | Reproductive (a) | Premenopausal (b) | Postmenopausal (c) | a-b | a-c | b-c |
| Glucose mg/dl | 86.5 (81—93.7) | 92.5 (85—112.8) | 94.5 (82.7—103) | 0.2332 | 0.1223 | > 0.9999 |
| Cholesterol mg/dl | 195.0 ± 28.2 | 204.0 ± 51.1 | 228.9 ± 51.4 | 0.8141 | 0.0280* | 0.0782 |
| Triglycerides mg/dl | 74.0 (53—88) | 130.5 (100—160) | 117.0 (93 -190) | 0.0006*** | 0.0002*** | > 0.9999 |
| HDL mg/dl | 62.5 (47.7—69.2) | 48.0 (43.7—58.5) | 54.0 (43.7—66.5) | 0.1534 | > 0.9999 | 0.3116 |
| LDL mg/dl | 120.8 ± 30.7 | 125.3 ± 41.8 | 143.2 ± 44.8 | 0.9352 | 0.1232 | 0.1725 |
| VLDL mg/dl | 15.0 (10.7—17.5) | 26.0 (20—32.2) | 23.0 (19—38) | 0.0007** | 0.0002*** | > 0.9999 |
| Lipoprotein A mg/dl | 21.7 (11.2—33.6) | 12.5 (4.4—45.3) | 22.7 (10.2—55.6) | > 0.9999 | > 0.9999 | 0.7908 |
| ApoA | 167.3 ± 32.6 | 165.5 ± 20.3 | 177.7 ± 34.5 | 0.9818 | 0.4409 | 0.2339 |
| ApoB | 93.0 (84—125.3) | 117.1 (95 -131.3) | 127.5 (98—152.8) | 0.5096 | 0.0195* | 0.5521 |
| Urea mg/dl | 23.5 (16—31) | 26.5 (25—35) | 30.5 (25.7—36.2) | 0.2418 | 0.0061** | 0.6262 |
| Creatinin mg/dl | 0.72 (0.67—0.78) | 0.72 (0.65—0.82) | 0.75 (0.68—0.86) | > 0.9999 | 0.7903 | 0.5458 |
| Calcium mg/dL | 9.37 ± 0,26 | 9.63 ± 0,39 | 9.83 ± 0,38 | 0.0579 | < 0.0001**** | 0.0558 |
| Phosphorus mg/dl | 3.44 ± 0,38 | 3.68 ± 0,48 | 3.70 ± 0,46 | 0.2157 | 0.0922 | 0.9722 |
| Uric acid mg/dl | 4.25 (3.4—4.9) | 4.8 (4.2—5.6) | 5.1 (4.4—5.9) | 0.0698 | 0.0102* | > 0.9999 |
| Reactive C protein | 1.51 (0.65—3.3) | 3.16 (1.3—6.9) | 3.08 (1.6—4.7) | 0.2091 | 0.1443 | > 0.9999 |
| Alkaline phosphatase U/l | 65.5 (52—80) | 80.5 (66—95) | 87.0 (73.2—105.5) | 0.0872 | 0.0008*** | 0.5501 |
| Vitamin D ng/ml | 24.0 ± 7.0 | 22.7 ± 7.1 | 23.5 ± 6.3 | 0.8010 | 0.9494 | 0.8835 |
| TSH mUI/dl | 1.8 (1.7—2.4) | 1.7 (1.1—2.9) | 2.2 (1.4—3.3) | > 0.9999 | > 0.9999 | 0.8978 |
| Testosterone ng/dl | 34.4 (19.8—45.4) | 34.2 (21.6—48.3) | 27.2 (18.5—39.3) | > 0.9999 | > 0.9999 | 0.2275 |
| Insulin µUI/ml | 6.4 (4.4—8.3) | 7.4 (4.4—11.1) | 6.7 (4.5—10.3) | 0.7279 | > 0.9999 | > 0.9999 |
| Cortisol µg/dl | 13.2 (9.6—19.4) | 17.4 (9.4—25.1) | 15.0 (9.6—21.4) | 0.8025 | > 0.9999 | > 0.9999 |
| SHBG µg/dl | 57.5 ± 18.3 | 45.8 ± 17.2 | 37.1 ± 14.7 | 0.0236* | < 0.0001**** | 0.0396* |
| SDHEA µg/dl | 74.7 (47—111.8) | 73.5 (49 – 102.8) | 58.8 (37.8—84.2) | > 0.9999 | 0.5580 | 0.0902 |
Data are expressed as the mean ± standard deviation (M ± SD). Data was tested using One Way ANOVA Test with post-test Tukey's multiple comparisons. Non-parametric data are expressed as median (1º and 3º Quartile) and the Kruskal–Wallis test was used. p < 0.05 was considered statistically significant. Reproductive n = 18; Premenopause n = 26; Postmenopause n = 58
HDL High-density lipoprotein, LDL Low-density lipoprotein, VLDL Very-low-density lipoprotein, ApoA Apoprotein A, ApoB Apoprotein B, TSH Thyrostimulating Hormone, SHBG Sex hormone-binding globulin, SDHEA dehydroepiandrosterone