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. 2022 Dec 6;20:387. doi: 10.1186/s12957-022-02849-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Volcano plot and hierarchical clustering analysis of DEPs in the sEVs from patients with HCC. A Volcano plot of protein expression in sEVs from patients with HCC compared to the control group. B Heatmap of the hierarchical clustering analysis of DEPs. Each column represents a set of samples (abscissa for sample information), and each row represents a protein (namely, the ordinate for SDEPs). The color scale shown in the map illustrates the relative protein expression: red represents upregulated proteins, blue represents downregulated proteins, and the blanks represent samples for which no quantitative information was available