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. 2022 Dec 6;20:566. doi: 10.1186/s12967-022-03774-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The CT-guided ¹²⁵I seed implantation procedure and therapeutic efficacy. Figure a–c showed the preoperative treatment plan, including the planned needle locations, seed distribution, target volume doses, and organs at risk in a case of locally recurrent embryonal rhabdomyosarcoma of the orbit after surgery and EBRT. The green or red needles and yellow seeds were the simulated needles and seeds in the brachytherapy treatment planning system. Figure d–f showed the actual locations of the needles before the seed implantation. Figure g–i showed the actual distribution of seeds and the doses in target volume and organs at risk after seed implantation. Figure j showed the 3D-printed non-coplanar template model with guide holes on it in brachytherapy treatment planning system. Figure k–m showed CT or PET-CT images of the tumor in preoperation, 3-month postoperation, and 6-month postoperation, and PET-CT showed no residual tumor with metabolic activity in Figure m [41]