Table 4.
Genes with statistically significant expression changes post HIFU, in the Soft Tissue Sarcoma group.
| Symbol | Description | Fold change | p-value |
|---|---|---|---|
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 11.3929 | .011236 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 10.925 | .011583 |
| DLA-DOB | major histocompatibility complex, class II, DO beta | 9.56251 | .007551 |
| CCL21 | chemokine (C-C motif) ligand 21 | 8.92264 | .021212 |
| TRBC | 7.90738 | .013974 | |
| CD22 | CD22 molecule | 7.8532 | .013559 |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 7.32257 | .017454 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 6.69229 | .015112 |
| SLAMF6 | SLAM family member 6 | 6.11109 | .024896 |
| CR1L | 6.07894 | .031854 | |
| SELE | selectin E | 5.95124 | .014139 |
| IL2RG | interleukin 2 receptor, gamma | 5.35498 | .044532 |
| TOX | thymocyte selection-associated high mobility group box | 5.32352 | .003619 |
| LCK | lymphocyte-specific protein tyrosine kinase | 5.12961 | .014522 |
| TNFSF11 | tumor necrosis factor (ligand) superfamily, member 11 | 4.78822 | .040326 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 4.27929 | .048927 |
| TNFRSF13C | tumor necrosis factor receptor superfamily, member 13C | 4.19875 | .014028 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 4.13925 | .010465 |
| S100A8 | S100 calcium binding protein A8 | 3.64829 | .037835 |
| LOC100049001 | tryptase | 3.11392 | .027965 |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | 2.92106 | .009146 |
| GH1 | growth hormone | 2.87671 | .00263 |
| LOC477699 | 2.53728 | .045067 | |
| NT5E | 5′-nucleotidase, ecto (CD73) | 2.42019 | .043786 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2.22728 | .014551 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.15832 | .039782 |
| VEGFA | vascular endothelial growth factor A | −3.06498 | .010696 |
| PLAUR | plasminogen activator, urokinase receptor | −3.71592 | .045821 |
Mean fold change in gene expression following HIFU treatment compared with baseline, normalized using housekeeping controls is presented.