TABLE 1.
Spleen cell cytokine secretion in B6, C3H, and BALB/c mice vaccinated with plasmid DNA encoding the 22-kDa antigen
| Mouse strain | Cytokine level (mean ± SD)
|
|||||
|---|---|---|---|---|---|---|
| IL-2 (cpm)a
|
IFN-γ (pg/ml)b
|
IL-6 (pg/ml)b
|
||||
| Control | 22 kDa | Control | 22 kDa | Control | 22 kDa | |
| C57BL/6 | 189 ± 27 | 2,236 ± 1,658 | 92 ± 119 | 846 ± 372 | 12 ± 10 | 217 ± 25 |
| C3H | 169 ± 26 | 1,699 ± 674 | 245 ± 219 | 774 ± 188 | 8 ± 4 | 213 ± 30 |
| BALB/c | 539 ± 258 | 641 ± 335 | 64 ± 81 | 160 ± 222 | 14 ± 7 | 133 ± 63 |
a
In 24-h spleen cell culture supernatants of five mice tested individually.
b
In 72-h spleen cell culture supernatants of five mice tested individually.