Fig. 2. Self-assembly of polymer-nanoparticle hydrogels is composition dependent. (A) Schematic of drug-loaded hydrogel assembly by guest–host interaction. (B) Oscillatory time sweeps of individual components (20%_w/v CDNP, green and 7.5%_w/v Ad-HA, blue) and formed polymer-CDNP hydrogel (1 : 1.5 ratio of 7.5%_w/v Ad-HA: 20%_w/v CDNP, purple); storage (G′, circles), and loss (G′′, squares) moduli at 1.0 Hz, 1.0% strain. (C) Storage and loss moduli of hydrogels formed from 82 kDa Ad-HA (low, left), 337 kDa Ad-HA (low, middle), and 82 kDa Ad-HA (high, right) at varying volumetric ratios of Ad-HA : CDNP. Time sweeps were performed at 10.0 Hz, 1.0% strain; mean ± SD, n = 2.