Table 1. Clinical Features of the Olink Cohort and the ELISA Cohorta.
| PE group | control group | P | |
|---|---|---|---|
| Olink Cohort | |||
| sample size | N = 15 | N = 15 | |
| PE types, n (%) | |||
| early-onset PE | 7 (46.67) | ||
| late-onset PE | 8 (53.33) | ||
| maternal age (years) | 31.53 ± 5.99 | 30.80 ± 2.98 | 0.680 |
| gestational age at delivery (weeks) | 35.57 (31.43, 37.71) | 39.29 (39.14, 39.57) | <0.001*** |
| BMI (kg/m2) | 27.96 ± 3.50 | 25.39 ± 1.91 | 0.020* |
| primipara, n (%) | 7 (46.67) | 6 (40.00) | 1.000 |
| maximum SBP (mmHg) | 170.00 (158.00, 180.00) | 110.00 (101.00, 114.00) | <0.001*** |
| maximum DBP (mmHg) | 104.93 ± 14.54 | 73.07 ± 6.20 | <0.001*** |
| neonatal birth weight (kg) | 2.10 ± 0.80 | 3.24 ± 0.27 | <0.001*** |
| sample collection time (weeks) | 34.74 ± 3.34 | 34.30 ± 1.76 | 0.657 |
| Late Pregnancy Cohort | |||
| sample size | N = 43 | N = 44 | |
| PE types, n (%) | |||
| early-onset PE | 18 (41.86) | ||
| late-onset PE | 25 (58.14) | ||
| maternal age (years) | 31.02 ± 6.34 | 29.84 ± 3.43 | 0.280 |
| gestational age at delivery (weeks) | 35.57 (32.57, 38.00) | 39.64 (39.14, 40.54) | <0.001*** |
| BMI (kg/m2) | 27.22 ± 4.96 | 26.11 ± 2.42 | 0.190 |
| primipara, n (%) | 19 (44.20) | 21 (47.70) | 0.830 |
| maximum SBP (mmHg) | 166.16 ± 17.31 | 111.77 ± 9.00 | <0.001*** |
| maximum DBP (mmHg) | 106.21 ± 11.79 | 74.41 ± 7.77 | <0.001*** |
| neonatal birth weight (kg) | 2.23 ± 0.77 | 3.30 ± 0.40 | <0.001*** |
| sample collection time (weeks) | 35.14 (32.14, 37.57) | 34.50 (32.71, 36.57) | 0.966 |
| Early Pregnancy Cohort | |||
| sample size | N = 37 | N = 37 | |
| PE types, n (%) | |||
| early-onset PE | 11 (29.73) | ||
| late-onset PE | 26 (70.27) | ||
| maternal age (years) | 31.32 ± 4.80 | 33.14 ± 4.44 | 0.100 |
| gestational age at delivery (weeks) | 37.43 (33.93, 38.71) | 39.43 (38.57, 40.42) | <0.001*** |
| BMI (kg/m2) | 27.10 (24.61, 29.05) | 25.90 (24.33, 26.84) | 0.100 |
| primipara, n (%) | 15 (40.54) | 13 (35.14) | 0.630 |
| maximum SBP (mmHg) | 159.16 ± 11.16 | 116.57 ± 9.29 | <0.001*** |
| maximum DBP (mmHg) | 102.22 ± 11.77 | 73.78 ± 7.73 | <0.001*** |
| neonatal birth weight (kg) | 2.47 ± 0.81 | 3.20 ± 0.30 | <0.001*** |
| sample collection time (weeks) | 12.50 ± 0.67 | 12.44 ± 0.65 | 0.725 |
a
***P < 0.001. The late pregnancy cohort refers to the pregnant women who provided late pregnancy plasma samples, and the early pregnancy cohort refers to the pregnant women who provided early pregnancy plasma samples for ELISA validation. Abbreviations: PE, preeclampsia; BMI, body mass index; SBP, systolic blood pressure; and DBP, diastolic blood pressure.