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. 2022 Nov 10;21(12):2920–2935. doi: 10.1021/acs.jproteome.2c00323

Table 2. Denature Midpoint (C1/2) and Melting Point (Tm) of the Serum Proteins.

Uniprot ID protein name no. of C1/2 sites C1/2 average C1/2 stdev C1/2 RSD (%) length (AA) mass (kDa) log 10(pg/mL)81 Tm(°C)
P02768 albumin 44 1.96 0.54 27 609 69.4 9.2 63.284
P01023 α2 macroglobulin 20 1.41 0.63 45 1474 163.3 9.0 6585
P02787 serotransferrin 17 1.72 0.80 47 698 77.1 9.1 71, 8485
P01024 compliment C3 13 1.80 0.51 28 1663 187.1 9.05 60, 7685
P00738 haptoglobin 12 1.59 0.76 47 406 45.2 8.9 6285
P02647 apolipoprotein A1 11 2.08 0.60 29 267 30.8 9 5884
P01876 IgA 9 1.47 0.67 45 353 37.7 NA 7285
P01859 IgG 9 1.82 0.77 42 326 35.9 NA 7185
P06727 apolipoprotein A4 8 1.31 0.48 37 396 45.4 8 50.5, 53.986
P0DOX5 IgG 8 1.49 0.53 36 449 49.3 NA 7185
P01009 α1 antitrypsin 7 1.58 0.79 50 418 46.7 8.4 59.684
P01860 IgG 7 1.64 0.86 53 377 41.3 NA 7185
P01861 IgG 7 1.35 0.91 68 327 35.9 8.5 7185
P01834 immunoglobin kappa constant 7 2.65 0.18 7 107 11.8 NA NA
P00739 haptoglobin-related protein 5 1.08 0.59 54 348 39.0 7.6 NA
P01871 IgM 5 1.77 0.62 35 453 49.4 8.2 7185
P01011 alpha-1-antichymotrypsin 4 1.48 0.70 47 423 47.7 8.0 5885
P02652 apolipoprotein A2 4 1.99 0.32 16 100 11.2 8.5 8087
P04114 apolipoprotein B100 4 1.57 0.37 24 4563 515.6 8.5 31.1, 57.1, 73.584
P08603 compliment factor H 4 1.78 0.19 11 1231 139.1 7.6 NA
P02042 hemoglobin subunit delta 4 1.76 0.63 35 147 16.1 7.5 NA
P02763 alpha-1-acidglycoprotein 1 3 1.09 0.78 72 201 23.5 8.2 5884
P04217 alpha-1B glycoprotein 3 0.84 0.19 23 495 54.3 7.9 NA
P00450 ceruloplasmin 3 1.78 0.24 13 1065 122.2 8.2 85.188
P0DOX6 IgM 3 2.14 0.17 8 576 63.5 NA 7185
P19823 interalpha-trypsin inhibitor heavy chain H2 3 1.32 0.32 24 946 106.5 7.3 NA
P01042 kininogen-1 3 2.07 0.95 46 644 71.9 8.6 NA
P02774 vitamin D binding protein 3 1.18 1.02 87 474 52.9 7.8 NA
P02765 alpha-2-HS-glycoprotein 2 2.16 0.94 44 367 39.3 7.9 NA
P02751 fibronectin 2 1.21 0.33 27 2477 272.4 7.6 6484
P06396 gelsolin 2 1.93 0.37 19 782 85.7 8.3 6089
P00734 prothrombin 2 2.02 0.29 14 622 70.0 7.1  
P02766 transthyretin 2 1.11 0.55 50 147 15.9 8.6 101.790
P04004 vitronectin 2 1.80 0.15 8 478 54.3 7.7 5991