Table 3.

Summary of treatment modalities used in each case in the fatal cohort.

Publication	Age	Antibiotic	Antiviral	Steroids	MTX	CYA	Biologic	IVIG	Phototherapy	Other Treatments
Bhide et al. (2019)	38 y	+		+	+
Xing et al. (2017)	43 y	+		+				+
Nofal et al. (2016)	9 y	+		+		+		+
Meziane et al. (2012)	65 y		+	+	+		+	+
Malnar et al. (2006)	60 y	+		+
Aytekin et al. (2005)	27 y	+	+	+				+		FFP and a high-calorie parenteral therapy
Cozzio et al. (2004)	72 y 26 y			+	+ +			+	+
Miyamoto et al. (2003)	76 y	+
Puddu et al. (1997)	43 y	+		+
Gungor et al. (1996)	52 y	+		+	+
De Cuyper et al. (1994)	82 y	+		+					+
Hoghton et al. (1989)	49 y	+	+	+	+				+

Attempted treatments (+), cyclosporine (CYA), fresh frozen plasma (FFP), intravenous immunoglobulins (IVIG), maintenance treatment (M), methotrexate (MTX) months (m), years (y).