Table 1.

FUDR dose modification

	Reference valuea	% FUDR dose
AST (at pump emptying or day of planned retreatment, whichever is higher)	0 to <2 × reference value	100
	2 to <3 × reference value	80
	3 to <4 × reference value	50
	>4 × reference value	Hold
Alk Phos (at pump emptying or day of planned retreatment, whichever is higher)	0 to <1.2 × reference value	100
	1.2 to <1.5 × reference value	50
	>1.5 × reference value	Hold
Total bilirubin (at pump emptying or day of planned retreatment, whichever is higher)	0 to <1.2 × reference value	100
	1.2 to <1.5 × reference value	50
	>1.5 × reference value	Hold

FUDR, floxuridine; AST, aspartate aminotransferase; Alk Phos, alkaline phosphatase.

^aIf a patient's alkaline phosphatase or total bilirubin showed a continual rise from day 1 of treatment, then the day 1 value was used as the reference value for that patient when determining whether to hold treatment and time of retreatment after hold.