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. Author manuscript; available in PMC: 2022 Dec 6.
Published in final edited form as: Cancer Cell. 2017 Apr 10;31(4):467–469. doi: 10.1016/j.ccell.2017.03.008

Figure 1. Pharmacologic Ascorbate Mediation of Cancer Cell Death.

Figure 1.

Pharmacologic ascorbate is a pro-drug for formation of extracellular H2O2. H2O2 diffuses intracellularly and interacts with iron or other metal centers to form reactive oxygen species (ROS). ROS modulate multiple downstream pathways and targets that induce cancer cell death.