Figure 3.

Heatmap illustrating toxicant:modulator interactions in three differentiated neuronal models. Differentiated human cells are labeled “dSH-SY5Y, “dLUHMES”, or “dNSC”. Among toxicant:modulator pairs tested, 16 did not show IC₅₀ shifts exceeding 3-fold for any of the three differentiated cell types, and are omitted from this Figure. Cell colors are as described in the Figure 2 legend except extended to show 2- to 16-fold IC₅₀ shifts. Modulator abbreviations and drug targets are listed in Table 1. “NT” indicates the toxicant did not kill the cells at the highest concentration tested, 100 μM; and “TOX” indicates the toxicant killed the cells at the lowest concentration tested, 15 nM