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. Author manuscript; available in PMC: 2022 Dec 6.
Published in final edited form as: Chem Res Toxicol. 2017 Dec 4;31(2):127–136. doi: 10.1021/acs.chemrestox.7b00290

Figure 4.

Figure 4.

Sensitization of dLUHMES cells to 10 μM 6HD (A), or 4 μM MAP (B) by glutathione synthesis inhibitor, BSO, is partially relieved by 100 μM GSH or 100 μM NAC. BSO alone (open circles) was moderately cytotoxic to dLUHMES cells; whereas A) 10 μM 6HD + BSO (filled squares) were highly toxic. Addition of 100 μM NAC (grey filled circles) or 100 μM GSH (open triangles) to 6HD + BSO or MAP + BSO moderated cytotoxicity.