|
|
All
n=744
|
TAPSE/PASP
|
|
Tertile 1
n=233
|
Tertile 2
n=244
|
Tertile 3
n=267
|
p-value
|
|
Demographic parameters
|
|
Age, years
|
77±9
|
77±9
|
77±9
|
78±8
|
0.31
|
|
Sex female, n (%)
|
414 (55.7)
|
141 (60.5)
|
137 (55.9)
|
136 (50.9)
|
0.10
|
|
Body surface area, m2
|
1.87±0.22
|
1.84±0.24
|
1.88±0.22
|
1.86±0.29
|
0.30
|
|
Hypertension, n (%)
|
581 (78.1)
|
179 (76.8)
|
203 (83.2)
|
199 (74.5)
|
0.049
|
|
Diabetes mellitus, n (%)
|
222 (29.8)
|
77 (33.0)
|
80 (32.8)
|
65 (24.3)
|
0.048
|
|
Coronary artery disease, n (%)
|
61.4 (457)
|
158 (67.8)
|
153 (62.7)
|
146 (54.7)
|
0.009
|
|
Atrial fibrillation, n (%)
|
505 (67.9)
|
154 (66.4)
|
171 (70.1)
|
181 (67.8)
|
0.68
|
|
Prior pacemaker/ICD/CRT, n (%)
|
288 (38.7)
|
98 (42.1)
|
100 (41.0)
|
90 (33.7)
|
0.11
|
|
Prior cardiac surgery, n (%)
|
206 (27.7)
|
90 (38.6)
|
72 (29.5)
|
44 (16.5)
|
<0.001
|
|
NT-pro-BNP, pg/ml
|
2971
[1525, 6345]
|
4295*
[2225, 8958]
|
2932
[1773, 6115]
|
1972
[949, 4517]
|
<0.001
|
|
Estimated GFR, ml/min/1.73m2
|
47.5±20.6
|
46.3±21.3
|
48.5±19.8
|
47.6±20.8
|
0.48
|
|
Logistic EuroSCORE, %
|
22.1
[10.1, 31.1]
|
22.1*
[13.3, 39.4]
|
17.4*
[10.6, 28.7]
|
13.2*
[8.1, 24.9]
|
<0.001
|
|
NYHA III/IV, n (%)
|
604 (81.2)
|
193 (83.2)
|
200 (82.0)
|
211 (79.0)
|
0.47
|
|
Echocardiographic parameters
|
|
LV ejection fraction, %
|
44.5±15.3
|
40.1±15.2*
|
44.7±15.3*
|
48.2±14.4*
|
<0.001
|
|
LV end-diastolic volume, ml
|
143.8±69.3
|
150.7±66.4
|
141.0±60.0
|
142.7±76.5
|
0.26
|
|
LV end-systolic volume, ml
|
86.0±57.5
|
95.4±57.7$
|
84.2±52.1
|
79.4±61.4
|
0.007
|
|
LA volume, ml
|
107.8±61.3
|
118.1±75.6$
|
108.1±55.2
|
98.7±51.3
|
0.004
|
|
Functional MR, n (%)
|
430 (57.8)
|
151 (64.8)
|
144 (59.0)
|
135 (50.6)
|
0.005
|
|
MR moderate-to-severe/severe, n (%)
|
634 (85.2)
|
192 (84.6)
|
205 (84.7)
|
237 (88.8)
|
0.29
|
|
TAPSE/PASP
|
0.43±0.25
|
0.23±0.05*
|
0.36±0.04*
|
0.67±0.28*
|
<0.001
|
|
PASP, mmHg
|
48.3±16.8
|
63.3±15.3*
|
48.6±10.6*
|
34.8±10.3*
|
<0.001
|
|
TAPSE, mm
|
17.9±5.1
|
14.2±3.6*
|
17.6±4.0*
|
21.3±4.9*
|
<0.001
|
|
RV fractional area change, %
|
38.2±11.9
|
33.5±11.5*
|
37.8±11.1*
|
42.6±11.4*
|
<0.001
|
|
RV end-diastolic area, mm2
|
21.3±7.6
|
22.8±7.4$
|
21.5±7.2
|
20.0±7.8
|
<0.001
|
|
Procedural parameters
|
|
Number of clips implanted
|
1.5±0.6
|
1.5±0.6
|
1.4±0.6
|
1.5±0.7
|
0.15
|
|
Post-procedural MR ≤moderate
|
684 (91.9)
|
215 (92.3)
|
222 (91.0)
|
247 (92.5)
|
0.80
|
|
Post-procedural transmitral pressure gradient, mmHg
|
3.9±1.8
|
3.7±1.8
|
4.0±1.8
|
3.9±1.7
|
0.12
|
|
*p<0.05 vs All by Tukey’s test. $p<0.05 vs Tertile 3 by Tukey’s test. CI: confidence interval; CRT: cardiac resynchronisation therapy; GFR: glomerular filtration ratio; HR: hazard ratio; ICD: intracardiac defibrillator; LA: left atrial; LV: left ventricular; MR: mitral regurgitation; NYHA: New York Heart Association; PASP: pulmonary artery systolic pressure; RV: right ventricular; TAPSE: tricuspid annular plane systolic excursion; TR: tricuspid regurgitation
|
