Table 3. Comparisons of diagnostic performance between different lesion and procedural characteristics.

		Sensitivity (n/N)	95% CI	p-value	Specificity (n/N)	95% CI	p-value
Main vessel	LAD	92.6% (87/94)	(85.1-96.4)	0.99	98.7% (78/79)	(91.5-99.8)	0.05
	LCx	100.0% (18/18)	N/A		86.3% (44/51)	(73.8-93.3)
	RCA	92.3% (24/26)	(73.5-98.1)		84.3% (43/51)	(71.5-92.0)
Lesion location	Proximal	90.4% (47/52)	(78.8-96.0)	0.71	91.5% (43/47)	(79.3-96.8)	0.12
	Mid	94.4% (67/71)	(85.8-97.9)		93.6% (102/109)	(87.1-96.9)
	Distal	100.0% (15/15)	N/A		80.0% (20/25)	(59.9-91.5)
Invasive FFR (FFRwire)	Grey zone (0.75-0.85)	88.5% (46/52)	(76.5-94.8)	0.08	85.1% (40/47)	(71.8-92.8)	0.10
	Beyond grey zone	96.5% (83/86)	(89.6-98.9)		93.3% (125/134)	(87.5-96.5)
Main branch/side branch	Main branch	93.1% (122/131)	(87.3-96.4)	0.97	92.2% (154/167)	(87.0-95.4)	0.10
	Side branch	100.0% (7/7)	N/A		78.6% (11/14)	(50.3-93.0)
Tortuosity	Yes	100.0% (9/9)	N/A	0.98	80.0% (4/5)	(30.6-97.3)	0.39
	No	92.7% (114/123)	(86.5-96.2)		91.6% (152/166)	(86.2-95.0)
Calcification	Yes	87.1% (27/31)	(70.0-95.1)	0.14	93.3% (28/30)	(76.7-98.3)	0.66
	No	95.0% (96/101)	(88.6-97.9)		90.8% (128/141)	(84.7-94.6)
FFR system	Philips/Volcano	94.0% (63/67)	(84.9-97.7)	0.16	93.8% (75/80)	(85.6-97.3)	0.47
	Abbott/St. Jude	95.2% (60/63)	(85.5-98.4)		88.8% (79/89)	(79.1-93.4)
	Opsens	75.0% (6/8)	(37.5-93.7)		91.7% (11/12)	(59.0-98.8)
Injection type	Intracoronary	96.6% (84/87)	(89.7-98.9)	0.07	92.4% (122/132)	(86.1-95.7)	0.30
	Intravenous	88.2% (45/51)	(74.8-94.3)		87.8% (43/49)	(74.0-94.0)
CI: confidence interval; FFR: fractional flow reserve; LAD: left anterior descending artery; LCx: left circumflex artery; RCA: right coronary artery