Table 3. Association between severity of PVR and clinical outcomes at two years.
| Clinical outcome | Paravalvular regurgitation | Unadjusted | Covariate-adjusted | Propensity score-adjusted | ||||
|---|---|---|---|---|---|---|---|---|
| ≤Mild | ≥Moderate | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| All-cause death | 13.3% (243) | 23.5% (27) | 1.94 (1.29-2.93) | 0.002 | 2.33 (1.41-3.85) | 0.001 | 1.82 (1.19-2.78) | 0.006 |
| Cardiovascular death | 7.3% (130) | 16.6% (18) | 2.55 (1.52-4.28) | <0.001 | 3.30 (1.74-6.28) | <0.001 | 2.51 (1.46-4.30) | <0.001 |
| Rehospitalisation | 15.6% (277) | 33.9% (37) | 2.09 (1.34-3.27) | 0.001 | 2.68 (1.57-4.58) | <0.001 | 2.26 (1.42-3.58) | <0.001 |
| Reintervention* | 0.6% (9) | 6.0% (6) | 11.89 (4.01-35.28) | <0.001 | 14.72 (3.13-69.32) | <0.001 | 11.99 (3.78-38.03) | <0.001 |
| Stroke | 4.8% (80) | 7.3% (7) | 1.53 (0.66-3.54) | 0.32 | 1.23 (0.43-3.51) | 0.69 | 1.34 (0.56-3.21) | 0.51 |
| Values are Kaplan-Meier event rates (number of patients with events). HRs are based on comparing ≥moderate versus ≤mild PVR. *Firth’s correction was applied to this model due to a low number of events. | ||||||||