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. 2022 Dec 6;2022(12):CD013601. doi: 10.1002/14651858.CD013601.pub2

Ibarra‐Sifuentes 2017.

Study characteristics
Methods Study characteristics

  • Study design: parallel RCT

  • Study duration: 1 April to 21 May 2016

  • Study follow‐up: 12 weeks
Participants Baseline characteristics

  • Country: Mexico

  • Setting: university hospital (1 site)

  • Inclusion criteria: men and non‐pregnant women, not breastfeeding; 18 to 85 years; regular attendance to HD sessions, at least twice/week; previous 6 months on HD treatment; 2 or more intradialytic hypotension episodes in the past 6 months

  • Randomised number (intervention/control): 18/15

  • Dialysis modality: HD

  • Mean age ± SD (years): intervention group (44.9 ± 16.9); control group (49 ± 12.1)

  • Sex (M/F): intervention group (7/11); control group (8/7)

  • Dialysis duration: not reported

  • Exclusion criteria: treated with L‐carnitine in the previous 6 months; septic stock history in the previous 6 months; pregnancy; lactation; and history of hypersensitivity or contraindication to L‐carnitine
Interventions Intervention group

  • L‐carnitine (IV): 30 mg/kg at dialysis session for 12 weeks


Control group

  • Placebo
Outcomes Outcomes relevant to this review

  • Myocardiac function: intradialytic hypotension
Notes Funding source: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "computerized random number generator and allocated into L‐ carnitine and placebo groups"
Allocation concealment (selection bias) Low risk Quote: "computerized random number generator and allocated into L‐carnitine and placebo groups"
Blinding of participants and personnel (performance bias) Low risk Quote: "double‐blind placebo‐controlled" study
Blinding of outcome assessment (detection bias)
Myocardial function Low risk Quote: "double‐blind placebo‐controlled" study
Incomplete outcome data (attrition bias)
Myocardial function Unclear risk Insufficient information to permit judgement
Selective reporting (reporting bias) Low risk Pre‐specified outcomes (of interest to this review) were reported
Other bias Unclear risk Funding source: not reported