Pacheco 2008.

Study characteristics
Methods	Study characteristics Study design: parallel RCT Study duration: not reported Study follow‐up: 12 weeks
Participants	Baseline characteristics Country: Chile Setting: university hospital (1 site) Inclusion criteria: chronic HD; 20 to 50 years Randomised number (intervention/control): 15/15 Dialysis modality: HD Mean age ± SD (years): intervention group (38.8 ± 9.5); control group (35.8 ± 11.4) Sex (M/F): intervention group (7/6); control group (4/4) Exclusion criteria: DM; COPD; CAD; HCT < 25%; BMI > 30
Interventions	Intervention group L‐carnitine (IV): 1000 mg at each dialysis for 12 weeks Control group Placebo
Outcomes	Outcomes relevant to this review Anaemia‐related markers: HCT
Notes	Funding: Labomed Chile provided carnitine
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "random number table"
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias)	Low risk	Quote: "double‐blind placebo‐controlled" study
Blinding of outcome assessment (detection bias) Anaemia‐related markers	Low risk	Quote: "double‐blind placebo‐controlled" study
Incomplete outcome data (attrition bias) Anaemia‐related markers	High risk	Imbalance in numbers for missing data across intervention groups
Selective reporting (reporting bias)	Unclear risk	The study protocol is not available
Other bias	High risk	Funding: Labomed Chile provided carnitine