Table 4. Endpoints by geography.
European Union | North America | p-value for interaction | |||||
---|---|---|---|---|---|---|---|
PCI (n=534) | CABG (n=541) | HR [95% CI] | PCI (n=381) | CABG (n=371) | HR [95% CI] | ||
30-day outcomes | |||||||
Death, MI, stroke | 4.7% | 8.5% | 0.52 [0.32-0.87] | 5.3% | 5.7% | 0.93 [0.49-1.74] | 0.09 |
Death | 1.5% | 1.1% | 1.32 [0.45-3.82] | 0.3% | 0.3% | 0.98 [0.06-15.72] | – |
MI | 3.2% | 6.6% | 0.46 [0.25-0.83] | 5.0% | 4.4% | 1.17 [0.59-2.32] | – |
Stroke | 0.6% | 1.1% | 0.49 [0.12-1.97] | 0.5% | 1.6% | 0.32 [0.06-1.61] | – |
Death, MI, stroke, IDR | 4.7% | 9.0% | 0.49 [0.30-0.80] | 5.3% | 6.0% | 0.88 [0.47-1.65] | 0.08 |
IDR | 0.6% | 1.5% | 0.37 [0.10-1.38] | 1.1% | 0.8% | 1.31 [0.29-5.89] | – |
Definite ST or GO | 0.4% | 1.3% | 0.28 [0.06-1.35] | 0.3% | 0.8% | 0.32 [0.03-3.13] | – |
3-year outcomes | |||||||
Death, MI, stroke | 15.1% | 15.4% | 0.97 [0.69-1.35] | 16.1% | 12.8% | 1.33 [0.88-2.02] | 0.16 |
Death | 7.7% | 6.3% | 1.24 [0.77-2.00] | 8.4% | 4.8% | 1.86 [1.01-3.43] | – |
MI | 7.5% | 8.6% | 0.84 [0.54-1.32] | 9.2% | 6.9% | 1.37 [0.80-2.34] | – |
Stroke | 2.3% | 3.9% | 0.58 [0.28-1.20] | 2.8% | 4.5% | 0.60 [0.27-1.34] | – |
Death, MI, stroke, IDR | 21.3% | 19.2% | 1.13 [0.83-1.53] | 26.5% | 17.9% | 1.71 [1.20-2.44] | 0.05 |
IDR | 10.5% | 6.9% | 1.53 [1.00-2.34] | 16.8% | 8.1% | 2.37 [1.47-3.81] | – |
Definite ST or GO | 1.0% | 5.3% | 0.17 [0.07-0.46] | 0.6% | 5.4% | 0.10 [0.02-0.42] | – |
5-year outcomes | |||||||
Death, MI, stroke | 21.1% | 19.6% | 1.09 [0.81-1.48] | 24.2% | 17.3% | 1.57 [1.09-2.26] | 0.07 |
Death | 12.2% | 10.2% | 1.24 [0.84-1.83] | 14.4% | 8.7% | 1.82 [1.13-2.92] | – |
MI | 9.6% | 9.5% | 0.98 [0.65-1.49] | 12.5% | 7.6% | 1.72 [1.04-2.85] | – |
Stroke | 3.2% | 5.0% | 0.62 [0.33-1.17] | 3.1% | 5.8% | 0.52 [0.25-1.11] | – |
Death, MI, stroke, IDR | 28.5% | 24.7% | 1.22 [0.92-1.61] | 36.9% | 24.1% | 1.91 [1.38-2.64] | 0.02 |
IDR | 13.4% | 9.3% | 1.53 [1.03-2.27] | 22.9% | 10.9% | 2.48 [1.63-3.78] | – |
Definite ST or GO | 1.4% | 6.4% | 0.20 [0.09-0.47] | 0.9% | 7.0% | 0.11 [0.03-0.38] | – |
Event rates are Kaplan-Meier estimates. CABG: coronary artery bypass graft; GO: graft occlusion; IDR: ischaemia-driven revascularisation; MI: myocardial infarction; PCI: percutaneous coronary intervention; ST: stent thrombosis |