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. 2022 Jan 28;17(13):1081–1090. doi: 10.4244/EIJ-D-21-00338

Table 4. Endpoints by geography.

European Union North America p-value for interaction
PCI (n=534) CABG (n=541) HR [95% CI] PCI (n=381) CABG (n=371) HR [95% CI]
30-day outcomes
Death, MI, stroke 4.7% 8.5% 0.52 [0.32-0.87] 5.3% 5.7% 0.93 [0.49-1.74] 0.09
Death 1.5% 1.1% 1.32 [0.45-3.82] 0.3% 0.3% 0.98 [0.06-15.72]
MI 3.2% 6.6% 0.46 [0.25-0.83] 5.0% 4.4% 1.17 [0.59-2.32]
Stroke 0.6% 1.1% 0.49 [0.12-1.97] 0.5% 1.6% 0.32 [0.06-1.61]
Death, MI, stroke, IDR 4.7% 9.0% 0.49 [0.30-0.80] 5.3% 6.0% 0.88 [0.47-1.65] 0.08
IDR 0.6% 1.5% 0.37 [0.10-1.38] 1.1% 0.8% 1.31 [0.29-5.89]
Definite ST or GO 0.4% 1.3% 0.28 [0.06-1.35] 0.3% 0.8% 0.32 [0.03-3.13]
3-year outcomes
Death, MI, stroke 15.1% 15.4% 0.97 [0.69-1.35] 16.1% 12.8% 1.33 [0.88-2.02] 0.16
Death 7.7% 6.3% 1.24 [0.77-2.00] 8.4% 4.8% 1.86 [1.01-3.43]
MI 7.5% 8.6% 0.84 [0.54-1.32] 9.2% 6.9% 1.37 [0.80-2.34]
Stroke 2.3% 3.9% 0.58 [0.28-1.20] 2.8% 4.5% 0.60 [0.27-1.34]
Death, MI, stroke, IDR 21.3% 19.2% 1.13 [0.83-1.53] 26.5% 17.9% 1.71 [1.20-2.44] 0.05
IDR 10.5% 6.9% 1.53 [1.00-2.34] 16.8% 8.1% 2.37 [1.47-3.81]
Definite ST or GO 1.0% 5.3% 0.17 [0.07-0.46] 0.6% 5.4% 0.10 [0.02-0.42]
5-year outcomes
Death, MI, stroke 21.1% 19.6% 1.09 [0.81-1.48] 24.2% 17.3% 1.57 [1.09-2.26] 0.07
Death 12.2% 10.2% 1.24 [0.84-1.83] 14.4% 8.7% 1.82 [1.13-2.92]
MI 9.6% 9.5% 0.98 [0.65-1.49] 12.5% 7.6% 1.72 [1.04-2.85]
Stroke 3.2% 5.0% 0.62 [0.33-1.17] 3.1% 5.8% 0.52 [0.25-1.11]
Death, MI, stroke, IDR 28.5% 24.7% 1.22 [0.92-1.61] 36.9% 24.1% 1.91 [1.38-2.64] 0.02
IDR 13.4% 9.3% 1.53 [1.03-2.27] 22.9% 10.9% 2.48 [1.63-3.78]
Definite ST or GO 1.4% 6.4% 0.20 [0.09-0.47] 0.9% 7.0% 0.11 [0.03-0.38]
Event rates are Kaplan-Meier estimates. CABG: coronary artery bypass graft; GO: graft occlusion; IDR: ischaemia-driven revascularisation; MI: myocardial infarction; PCI: percutaneous coronary intervention; ST: stent thrombosis