Table 2. Change in ambulatory and office blood pressure at 2 and 6 months.
Pre-crossover baseline* | 2 months* | Change from pre-crossover baseline to 2M | p-value* | Pre-crossover baseline# | 6 months# | Change from pre-crossover baseline to 6M | p-value | |
Daytime ABP, mmHg | n=33 | n=33 | n=27 | n=27 | ||||
SBP | 144.1±10.1 | 132.8±14.5 | –11.2±13.7 | <0.001 | 144.6±11.0 | 133.8±16.5 | –10.8±17.3 | 0.002 |
DBP | 89.9±8.4 | 82.9±9.5 | –7.1±8.9 | <0.001 | 90.4±8.7 | 82.6±8.8 | –7.8±11.6 | <0.001 |
24-hour ABP, mmHg | n=33 | n=33 | n=27 | n=27 | ||||
SBP | 137.6±11.2 | 126.5±14.6 | –11.1±13.3 | <0.001 | 138.9±11.7 | 128.6±15.6 | –10.2±16.0 | <0.001 |
DBP | 85.2±8.7 | 78.0±9.1 | –7.3±8.6 | <0.001 | 86.1±8.9 | 78.5±8.0 | –7.6±10.8 | <0.001 |
Night-time ABP, mmHg | n=33 | n=33 | n=27 | n=27 | ||||
SBP | 127.4±15.3 | 116.6±16.4 | –10.9±14.1 | <0.001 | 129.9±15.3 | 120.5±16.2 | –9.3±15.6 | 0.003 |
DBP | 77.7±10.6 | 70.4±10.0 | –7.2±9.4 | <0.001 | 79.2±10.3 | 72.1±9.0 | –7.1±10.6 | <0.001 |
Office BP, mmHg | n=31 | n=31 | n=26 | n=26 | ||||
SBP | 146.4±18.3 | 139.9±17.5 | –6.5±18.0 | 0.025 | 145.6±20.9 | 142.1±20.0 | –3.5±1 9.4 | 0.393 |
DBP | 94.6±10.4 | 89.4±11.1 | –5.3±10.3 | 0.003 | 94.7±10.4 | 91.6±10.7 | –3.1±10.8 | 0.170 |
Data displayed as mean±SD. p-value for change from baseline is from signed-rank test. *Matched 2-month data. #Matched 6-month data. ABP: ambulatory blood pressure; BP: blood pressure; DBP: diastolic blood pressure; SBP: systolic blood pressure |