Figure 6.

Weighted composite endpoint (WCE). A) Flow chart for analysis. In this explanation, event weights of death, stroke, and myocardial infarction (MI) are assigned as 1.0, 0.47, and 0.38, respectively. A1. Each group. A2. Patient level assessment. The residual weights and event weights in each patient are calculated as follows. (a) No events occur at follow-up, a weight of 1.0 remains unaltered. (b) A patient with a myocardial infarction on day 1 and a non-disabling stroke on day 11 has a cumulative weighting of 0.3286=1–[(1–0.38)×(1–0.47)]. When the patient suffers the second stroke on day 30, the patient has a residual weighting of 0.174158=0.3286×(1–0.47). (c) If a death is the only event, a weight of 1.0 is lost for a death event. (d) If there is an event before a death, the residual weight is lost for a death. A3. Group assessment. (a) Calculation of weighted number of patients at risk (residual weight) and cumulative weighted event-free rate. (b) The table is an example when the number of patients is 20. A modified life table including weighted number of patients at risk and cumulative weighted event-free rate is created from each patient’s data. B) Application of WCE method to the DELTA registry. This figure is reproduced with permission from Capodanno et al3. CABG: coronary artery bypass grafting; CI: confidence interval; LMCA: left main coronary artery disease; MACCE: major adverse cardiac or cerebrovascular events; PCI: percutaneous coronary intervention