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. 2000 Mar;68(3):1069–1079. doi: 10.1128/iai.68.3.1069-1079.2000

FIG. 4.

FIG. 4

Partial alignment of the L. pneumophila IraA protein sequence with prokaryotic homologs. The sequences are derived from L. pneumophila (Lp) IraA, Acetobacter aceti (Aa) phosphatidylethanolamine N-methyltransferase (Pmt) (Hanada et al., unpublished), Thermotoga maritima (Tm) ubiquinone/menaquinone biosynthesis methyltransferase (UbiE) (53), Streptomyces griseus (Sg) carotenoid biosynthetic gene (CrtT) (68), Chlamydia pneumoniae (Cp) UbiE (S. Kalman, W. Mitchell, R. Marathe, C. Lammel, J. Fan, J. Olinger, J. Grimwood, R. W. Dain S, and R. S. Stephens, GenBank accession no. AEOO-1636 [unpublished results]), and Rhodobacter sphaeroides (Rs) Pmt (5). Alignments were achieved using CLUSTALW (72). In the consensus sequence, invariant residues are indicated in capitals, highly conserved residues are indicated in lowercase type, o indicates any hydrophobic amino acid, and s indicates a small amino acid. Regions corresponding to the two signature sequences unique to this class of proteins are indicated in bold type.