Table 1. Main features of the included studies.

Study, year	Acronym	Patient population	Type of study	Mean follow-up (months)	Patients (N)	Deaths (N)	Mean age (years)	Female (%)	Diabetes (%)	ACS (%)	PCI (%)
Ndrepepa et al, 2008		NSTE-ACS and elective patients undergoing PCI	RCT	12	5,384	197	66.6	25	34	38	100
Mehran et al, 2009	ACUITY	ACS patients	RCT	12	13,819	524	62.6	30	28	100	56.4
Montalescot et al, 2009	STEEPLE	Patients undergoing PCI	RCT	12	2,636	75	63.7	26	29	0	100
Lindsey et al, 2009	EVENT	Patients undergoing PCI	registry	12	5,961	167	64.7	33	35	34	100
Kim et al, 2011		Patients undergoing PCI	registry	36	3,148	134	60.5	29	27	14	100
Kikkert et al, 2013		STEMI patients undergoing PCI	registry	48	2,002	366	62.0	30	14	100	100
Stone et al, 2014	HORIZONS- AMI	STEMI patients undergoing PCI	RCT	36	3,202	197	59.9	23	16	100	100
Kazi et al, 2015		Patients undergoing PCI	registry	53	32,906	4,048	64.0	30	27	68	100
Généreux et al, 2015 and Stone et al, 2013	ADAPT-DES	Patients undergoing PCI	registry	24	8,577	311	63.6	26	32	52	100
Baber et al, 2016	PARIS	Patients undergoing PCI	registry	24	5,018	227	63.7	25	33	41	100
Garot et al, 2017	LEADERS FREE	High bleeding-risk patients undergoing PCI	RCT	24	2,386	320	75.7	30	56	72	100
Valgimigli et al, 2017	TRACER	NSTE-ACS patients	RCT	16	12,702	500	64.0	28	31	100	57.8
Palmerini et al, 2017		Patients undergoing PCI	pooled RCTs	18	11,473	267	63.1	30	31	42	100
Secemsky et al, 2017	DAPT	Patients undergoing PCI without ischaemic or bleeding events after 12 months of DAPT	RCT	21	11,648	222	61.3	25	29	46	100
Caneiro-Queija et al, 2018		ACS patients	registry	15	4,229	335	67.0	25	32	100	73.5
Hara et al, 2020	GLOBAL LEADERS	Patients undergoing PCI	RCT	24	15,968	477	64.5	23	19	47	100