. 2022 Feb 4;17(14):e1126–e1196. doi: 10.4244/EIJ-E-21-00009

Table 10. Target international normalized ratio for mechanical prostheses.

Prosthesis thrombogenicity	Patient-related risk factors^a
Prosthesis thrombogenicity	None	≥1 risk factor
Low^b	2.5	3.0
Medium^c	3.0	3.5
High^d	3.5	4.0
AF: atrial fibrillation; LVEF: left ventricular ejection fraction. ^aMitral or tricuspid valve replacement; previous thromboembolism; AF; mitral stenosis of any degree; LVEF <35%. ^bCarbomedics, Medtronic Hall, ATS, Medtronic Open-Pivot, St Jude Medical, Sorin Bicarbon. ^cOther bileaflet valves with insufficient data. ^dLillehei-Kaster, Omniscience, Starr-Edwards (ball-cage), Bjork-Shiley and other tilting-disc valves.