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. 2022 Feb 4;17(14):e1126–e1196. doi: 10.4244/EIJ-E-21-00009

Table 7. Severe mitral regurgitation criteria based on 2D echocardiography.

Primary mitral regurgitation Secondary mitral regurgitation
Qualitative
Mitral valve morphology Flail leaflet, ruptured papillary muscle, severe retraction, large perforation Normal leaflets but with severe tenting, poor leaflet coaptation
Colour flow jet area Large central jet (>50% of LA) or eccentric wall impinging jet of variable size Large central jet (>50% of LA) or eccentric wall impinging jet of variable size
Flow convergence Large throughout systole Large throughout systole
Continuous wave Doppler jet Holosystolic/dense/triangular Holosystolic/dense/triangular
Semiquantitative
Vena contracta width (mm) ≥7 (≥8 mm for biplane) ≥7 (≥8 mm for biplane)
Pulmonary vein flow Systolic flow reversal Systolic flow reversal
Mitral inflow E-wave dominant (>1.2 m/s) E-wave dominant (>1.2 m/s)
TVI mitral/TVI aortic >1.4 >1.4
Quantitative
EROA (2D PISA, mm2) ≥40 mm2 ≥40 mm2 (may be ≥30 mm2 if elliptical regurgitant orifice area)
Regurgitant volume (mL/beat) ≥60 mL ≥60 mL (may be ≥45 mL if low flow conditions)
Regurgitant fraction (%) ≥50% ≥50%
Structural
Left ventricle Dilated (ESD ≥40 mm) Dilated
Left atrium Dilated (diameter ≥55 mm or volume ≥60 mL/m2) Dilated
2D: two-dimensional; ESD: endsystolic diameter; EROA: effective regurgitant orifice area; LA: left atrium; PMR: primary mitral regurgitation; SMR: secondary mitral regurgitation; PISA: proximal isovelocity surface area; TVI: time-velocity integral. Adapted from Lancellotti P et al. Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging 2013;14:611-644. Copyright (2013) by permission of Oxford University Press on behalf of the European Society of Cardiology. Reproduced from Zoghbi WA et al. Recommendations for noninvasive evaluation of native valvular regurgitation: a report from the American Society of Echocardiography developed in collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr 2017;30:303-371. Copyright (2017), with permission from the American Society of Echocardiography.