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. 2022 Dec 2;15:7077–7093. doi: 10.2147/IDR.S388568

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© 2022 Sun et al.

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Overview of T-SPOT.TB in diagnosis for tuberculosis. (A and B) The distribution of ESAT-6 and CFP-10 results of enrolled patients were shown, which is shewed extremely. (C and D) Spots count of ESAT-6 and CFP-10 are higher in ATB patients compare with non-ATB. The results of ESAT-6 and CFP-10 were both observed higher in active tuberculosis than non-active tuberculosis (p<0.001). (E) The ROC curve of ESAT-6 and CFP-10 for ATB. ESAT-6: AUC=0.788, 95% CI (0.739,0.837); CFP-10: AUC=0.794, 95% CI (0.744,0.844). (F) Max means the larger spots count in ESAT-6 or CFP-10: AUC=0.809, 95% CI (0.760 0.857). Min means the lowest spots count in ESAT-6 or CFP-10: AUC=0.788, 95% CI (0.737, 0.838). Sum means the spots count of ESAT-6 plus CFP-10: AUC=0.807, 95% CI (0.759, 0.856).

Abbreviations: ATB, active tuberculosis; ESAT-6, early secretory antigenic target; CFP-10, culture filtrate protein-10; ROC, receiver operator characteristic; AUC, area under the curve; 95% CI, 95% confidence interval.