Type of vaccine	Reference ID	Register	Phase	Vaccine	Comparator	Sample size	Participants/centre/location
RNA‐based vaccine	Roozen 2021	NL9275	1‐2	mRNA‐1273 20 μg ID	mRNA‐1273 20 μg IM	30	Healthy adults/single centre/the Netherlands
	Low 2021	NCT04480957	1‐2	ARCT‐021  (1 μg; 5 μg; 7.5 μg; 10 μg)	Placebo	106	Healthy adults/single centre/Singapore
	Li 2021b	ChiCTR2000034825 NCT04523571	1	BNT162b1 10 μg	BNT162b1 30 μg	144	Healthy young adults/single centre/China
	Mulligan 2020	NCT04368728	1‐2	BNT162b1 (10 μg; 30 μg; 100 μg)	Placebo	45	Healthy adults/2 centres/USA
Non‐replicating viral vector	Ramasamy 2020	NCT04400838; ISRCTN, 15281137	2/3	ChAdOx1 (2.2 × 1010 vp; 1 or 2 doses)	MenACWY	300	Healthy adults/2 centres/UK
Inactivated virus	Wu 2021c	NCT04552366	1	Ad5‐nCoV 0.2 mL neb 2D	Ad5‐nCoV (0.1 mL neb 2D; 0.5 mL IM + 0.2 mL neb; 0.5 mL IM; 1.0 mL IM)	130	Adults/single centre/China
	Zhu 2020	NCT04341389	2	Ad5‐vectored (1 × 1011 vp; 5 × 1010 vp)	Placebo	508	Healthy young adults/single centre/China
	Zhu 2022	NCT04566770	2	Ad5‐vectored (3 × 1010 vp)	Placebo	400	Healthy children and adolescents/single centre/China
	Che 2021	NCT04412538	2	KMS‐1 (100 EU; 150 EU) D0/14; D0/28 KMS‐1	Placebo	750	Healthy adults/2 centres/China
	Lazarus 2021	NCT04671017, ISRCTN 82411169	1‐2	VL A2001 3 AU	VL A2001 35 AU; 7 AU	153	Healthy adults/4 centres/UK
	Pan 2021a	NCT04758273	1	KCONVAC 5 μg	KCONVAC 10 μg	60	Healthy adults/single centre/China
	Pan 2021a	NCT04756323	2	KCONVAC (5 μg; 10 μg) (D0/14; D0/28)	Placebo	500	Healthy adults/single centre/China
	Pitisuttithum 2021	NCT04764422	1	NDV‐HXP‐S (1 μg; 1 μg + CpG1018; 3 μg; 3 μg + CpG1018; 10 μg)	Placebo	210	Healthy adults/single centre/Thailand
	Pu 2021	NCT04412538	1	KMS‐1 100 EU D0/14; D0/28	Placebo	192	Healthy adults/single centre/China
	Zakarya 2021	NCT04530357	1	QazCovid‐in	Placebo	44	Healthy adults/single centre/Kazakhstan
Protein subunit	Chappell 2021	NCT04495933	1	SARS‐CoV‐2 Sclamp  (5 μg; 15 μg; 45 μg)	Placebo	120	Healthy adults/single centre/Australia
	Goepfert 2021	NCT04537208	1‐2	CoV2 preS dTM LD + AFO3 CoV2 preS dTM LD + ASO3 CoV2 preS dTM HD + AFO3 CoV2 preS dTM HD + ASO3 CoV2 preS dTM HD	Placebo	271	Healthy adults/10 centres/USA
	Hsieh 2021	NCT04695652	2	MVC‐COV1901	Placebo	3854	Healthy adults/11 centres/Taiwan
	Zhang 2021b	ChiCTR2100045108	1	V‐01 (10 μg; 25 μg; 50 μg)	Placebo	180	Healthy adults/single centre/China
	Meng 2021b	NCT04530656	1	Sf9 cells vaccine (low dose in 2 doses; high dose in 2 or 3 doses)	Placebo	168	Healthy adults/single centre/China
	Meng 2021b	NCT04640402	2	Sf9 cells vaccine (low dose or high dose in 2 or 3 doses)	Placebo	960	Healthy adults/single centre/China
	Nguyen 2021	NCT04683484	2	Nanocovax  (25 μg; 50 μg; 75 μg)	Placebo	560	Healthy adults/2 centres/Vietnam
	Nguyen 2021	NCT04683484	1	Nanocovax  (25 μg; 50 μg)	Nanocovax 75 μg	60	Healthy adults/2 centres/Vietnam
	Richmond 2021	NCT04405908	1	SCB‐2019  (3 μg; 3 μg + AS03; 3 μg + CpG/Alum; 9 μg; 9 μg + AS03 9 μg + CpG/Alum; 30 μg; 30 μg + AS03; 30 μg + CpG/Alu)	Placebo	151	Healthy adults/single centre/Australia
	Ryzhikov 2021	NCT04527575	2	EpiVacCorona	Placebo	86	Healthy adults/single centre/Russia
	Shu 2021	ChiCTR2100045107	2	V‐01 (10 μg; 25 μg; 50 μg)	Placebo	880	Healthy adults/single centre/China
	Sridhar 2021	NCT04762680	2	CoV2 preS dTM (15 µg; 10 µg)	CoV2 preS dTM 5 µg	722	Adults with and without prior SARS‐CoV‐2 infection and risk factors for severe disease/20 centres/USA and Honduras
	Yang 2021	NCT04466085	2	ZF2001 (25 μg 2 doses; 50 μg 2 doses; 25 μg 3 doses; 50 μg 3 doses)	Placebo	900	Healthy adults/single centre/China
	Yang 2021	NCT04445194	2	ZF2001 (25 μg 3 doses; 50 μg 3 dose)	Placebo	50	Healthy adults/single centre/China
DNA‐based vaccine	Mammen 2021	NCT04642638		INO‐4800 (1 mg; 2 mg) D0/28	Placebo	201	Healthy adults/19 centres/USA
Virus‐like particle (VLP)	Gobeil 2021	NCT04636697		CoVLP 3.75 μg + AS03	Placebo	753	Healthy adults/multiple centres/Canada and USA
	Ward 2021b	NCT04450004		CoVLP (3.75 μg with CpG1018, AS03 or without adjuvant; 7.5 μg with CpG1018, AS03 or without adjuvant; 15 μg with CpG1018, AS03 or without adjuvant)	Placebo	180	Canada