Study ID | Study follow‐up (months) | ChAdOx1 (n) | Placebo (n) | Critical outcomes | ||||||
Confirmed SARS‐CoV‐2 infection after complete vaccination | Confirmed symptomatic COVID‐19 after complete vaccination | Severe or critical COVID‐19 | All‐cause mortality | Systemic reactogenicity events | Any AE | SAE | ||||
Asano 2022 (NCT04568031) | 1.9 | 192 | 64 | * | * | * | ✓ | ✓ | ✓ | ✓ |
Falsey 2021 (NCT04516746) | 6.27 | 21,635 | 10,816 | ✓ | ✓ | ✓ | ✓ | * | ✓ | ✓ |
Clemens 2021a (ISRCTN89951424) | 8.27 | 5207 | 5209 | * | ✓ | ✓ | ✓ | X | * | X |
Emary 2021 (NCT04400838) |
4.93 | 5600 | 5211 | * | ✓ | * | * | * | * | * |
Madhi 2021b (NCT04444674; PACTR202006922165132) |
2 | 52 | 52 | * | * | * | ✓ | * | * | ✓ |
Madhi 2021a (NCT04444674; PACTR202006922165132) |
6.73 | 1013 | 1013 | * | ✓ | * | * | * | * | * |
Kulkarni 2021 (CTRI/2020/08/027170) | 6 | 900 | 300 | * | * | * | ✓ | X | ✓ | ✓ |
Voysey 2021a (NCT04324606; ISRCTN89951424; NCT04400838; NCT04444674) | 3.94 | 12,408 | 12,014 | ✓ | ✓ | ✓ | ✓ | * | ✓ | ✓ |
Voysey 2021ab (ISRCTN89951424; NCT04324606; NCT04400838; NCT04444674) | 3.94 | 12,048 | 12,014 | ✓ | ✓ | ✓ | ✓ | * | ✓ | ✓ |