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. 2022 Dec 7;2022(12):CD015477. doi: 10.1002/14651858.CD015477
Study ID Study follow‐up (months) ChAdOx1 (n) Placebo (n) Critical outcomes
Confirmed SARS‐CoV‐2 infection after complete vaccination Confirmed symptomatic COVID‐19 after complete vaccination Severe or critical COVID‐19 All‐cause mortality Systemic reactogenicity events Any AE SAE
Asano 2022 (NCT04568031) 1.9 192 64 * * * ✓  ✓  ✓  ✓ 
Falsey 2021 (NCT04516746) 6.27 21,635 10,816 ✓  ✓  ✓  ✓  * ✓  ✓ 
Clemens 2021a (ISRCTN89951424) 8.27 5207 5209 * ✓  ✓  ✓  X * X
Emary 2021
(NCT04400838)
4.93 5600 5211 * * * * * *
Madhi 2021b 
(NCT04444674; PACTR202006922165132)
2 52 52 * * * ✓  * ✓ 
Madhi 2021a 
(NCT04444674; PACTR202006922165132)
6.73 1013 1013 * * * * * *
Kulkarni 2021 (CTRI/2020/08/027170) 6 900 300 * * * ✓  X ✓  ✓ 
Voysey 2021a (NCT04324606; ISRCTN89951424; NCT04400838; NCT04444674) 3.94 12,408 12,014 ✓  ✓  ✓  ✓  * ✓  ✓ 
Voysey 2021ab (ISRCTN89951424; NCT04324606; NCT04400838; NCT04444674) 3.94 12,048 12,014 ✓  ✓  ✓  ✓  * ✓  ✓