Type of vaccine	Study ID	Arms  (number analyzed)	Intervention	Nervous system diseases
RNA‐based vaccine	Thomas 2021	Intervention (21,926)	BNT162b2	NR
		Control (21,921)	Placebo	NR
	Frenck 2021	Intervention (1131)	BNT162b2	NR
		Control (1129)	Placebo	NR
	Walsh 2020	Intervention (24)	BNT162b2	NR
		Control (18)	Placebo	NR
	El Sahly 2021	Intervention (15,166)	mRNA‐1273	2 embolic stroke; 0 ischaemic stroke
		Control (15,151)	Placebo	0 embolic stroke; 1 ischaemic stroke
	Ali 2021	Intervention (2482)	mRNA‐1273	NR
		Control (1238)	Placebo	NR
	Kremsner 2021	Intervention (2002)	CVnCoV	NR
		Control (1980)	Placebo	NR
	Hall 2021	Intervention (60)	mRNA‐1273 boost	NR
		Control (59)	mRNA‐1273/placebo	NR
Non‐replicating viral vector	Madhi 2021b	Intervention (52)	ChAdOx1	16
		Control (52)	Placebo	10
	Falsey 2021	Intervention (21,587)	ChAdOx1	34 paresthesia
		Control (10,792)	Placebo	16 paresthesia
	Voysey 2021a	Intervention (12,021)	ChAdOx1	1 ischaemic stroke
		Control (11,724)	Placebo	0 ischaemic stroke
	Asano 2022	Intervention (192)	ChAdOx1	NR
		Control (64)	Placebo	NR
	Kulkarni 2021	Intervention (300)	SII‐ChAdOx1	NR
		Control (100)	ChAdOx1	NR
	Sadoff 2021a	Intervention (323)	Ad26.COV2.S	NR
		Control (163)	Placebo	NR
	Sadoff 2021b	Intervention (21,895)	Ad26.COV2.S	NR
		Control (21,888)	Placebo	NR
	Logunov 2021	Intervention (16,427)	Gam‐COVID‐Vac	0 haemorrhagic stroke; 1 paraesthesia
		Control (5435)	Placebo	1 haemorrhagic stroke; 1 paraesthesia
Inactivated virus	Ella 2021a	Intervention (99)	BBV152	NR
		Control (73)	Adjuvant	NR
	Ella 2021b	Intervention (12,879)	BBV152	NR
		Control (12,874)	Adjuvant	NR
	Zhang 2021	Intervention (24)	CoronaVac	NR
		Control (24)	Adjuvant	NR
	Zhang 2021	Intervention	CoronaVac	NR
		Control	Adjuvant	NR
	Bueno 2021	Intervention (270)	CoronaVac	NR
		Control (164)	Adjuvant	NR
	Han 2021	Intervention (217)	CoronaVac	NR
		Control (114)	Adjuvant	NR
	Palacios 2020	Intervention (6202)	CoronaVac	NR
		Control (6194)	Adjuvant	NR
	Wu 2021a	Intervention  (124)	CoronaVac	NR
		Control (74)	Adjuvant	NR
	Al Kaabi 2021	Intervention (13,464)	WIV04 Al Kaabi	NR
		Intervention (13,471)	HBO2	NR
		Control (13,453)	Adjuvant	NR
	Tanriover 2021	Intervention  (6646)	CoronaVac	NR
		Control (3568)	Adjuvant	1 acute cerebellar infarction
	Fadlyana 2021	Intervention (405)	CoronaVac	51
		Control (135)	Adjuvant	20
	Xia 2020	Intervention (84)	WIBP‐CorV	NR
		Control (28)	Adjuvant	NR
	Xia 2021	Intervention (252)	BBIBP‐CorV	NR
		Control (252)	Adjuvant	NR
	Guo 2021	Intervention (84)	WIBP‐CorV	NR
		Control (28)	Adjuvant	NR
Protein subunit	Formica 2021	Intervention (258)	NVX‐CoV2373	5
		Control (255)	Placebo	4
	Keech 2020	Intervention (29)	NVX‐CoV2373	NR
		Control (23)	Placebo	NR
	Shinde 2021	Intervention (484)	NVX‐CoV2373	0
		Control (484)	Placebo	1
	Heath 2021	Intervention (7569)	NVX‐CoV2373	32
		Control (7570)	Placebo	31
	Dunkle 2021	Intervention (19,965)	NVX‐CoV2373	2 stroke
		Control (9984)	Placebo	0 stroke
	Toledo‐Romani 2021	Intervention (14,675)	FINLAY‐FR‐2	NR
		Intervention (14,679)	FINLAY‐FR‐2/boostwe FR‐1	NR
		Control (14,677)	Placebo	NR
Homologous versus heterologous scheme	Li 2021a	Intervention (51)	CoronaVac/Ad5	NR
		Control (50)	CoronaVac	NR
	Liu 2021	Intervention (115)	ChAdOx1/BNT162b2	NR
		Control  (114)	ChAdOx1/ ChAdOx1NR	NR
		Intervention (119)	BNT162b2/ChAdOx1	NR
		Control  (115)	BNT162b2/BNT162b2	NR
Homologous or heterologous booster versus heterologous booster	Bonelli 2021	Intervention  (27)	ChAdOx1 booster	0 neurological complications
		Control (28)	BNT162b2 or mRNA‐1273 booster	0 neurological complications
	Sablerolles 2021	Control (105)	Ad26.COV2.S/no booster	NR
		Intervention (106)	Ad26/booster	NR
		Intervention (112)	Ad26/booster mRNA‐1273	NR
		Intervention (111)	Ad26/booster BNT162b2	NR
	Mok 2021	Intervention (30)	CoronaVac/booster	NR
		Control (30)	CoronaVac/booster BNT162b2	NR
	Li 2021a	Intervention (96)	CoronaVac/boost Ad5	NR
		Control (102)	CoronaVac/booster	NR
NR: not reported; RNA: ribonucleic acid.