TABLE 3.
Effect of Hyperchloremia on Death or Severe Disability and Death in Patients With Traumatic Brain Injury in Multivariate Analysis
| Strata Defined Presence or Absence of Hyperchloremia | Rates of Death, Vegetative State, or Severe Disability at 180 d, n (%) | OR(95% CI) | Rates of Death Within 180 d, n (%) | OR (95% CI) |
|---|---|---|---|---|
| Model 1a | ||||
| No hyperchloremia | 118 (47.8) | Reference | 52 (21.1) | Reference |
| Single occurrence of hyperchloremia | 73 (44.5) | 0.90 (0.55–1.46) | 40 (24.4) | 1.53 (0.84–2.77) |
| Two or more occurrences of hyperchloremia | 379 (65.3) | 1.81 (1.19–2.75) | 190 (32.8) | 1.89 (1.14–3.08) |
| Model 2b | ||||
| No hyperchloremia | 118 (47.8) | Reference | 52 (21.1) | Reference |
| Single occurrence of hyperchloremia | 73 (44.5) | 0.77 (0.46–1.28) | 40 (24.4) | 1.12 (0.59–2.11) |
| Two or more occurrences of hyperchloremia | 379 (65.3) | 1.62 (0.89–2.96) | 190 (32.8) | 2.35 (1.21–4.61) |
OR = odds ratio.
aModel 1 adjusted for age, admission Glasgow Coma Scale score, randomized group, CT scan classification (Marshall grades), and Injury Severity Score.
bModel 2 adjusted for age, admission Glasgow Coma Scale score, randomized group, CT scan classification (Marshall grades), Injury Severity Score, and total fluids administered in first 24 hr (continuous variable) and an interaction term between total fluids administered in first 24 hr and hyperchloremia.