TABLE 3.

Cleavage specificity of P. gingivalis DPPIV on synthetic peptides

Peptide	Cleavage sitea
1 (substance P)	H-Arg-Pro↓Lys-Pro↓Gln-Gln-Phe-Phe-Gly-Leu-Met-OH
2	H-Arg-Pro↓Lys-Pro↓Gln-Gln-Phe-OH
3	H-Ser-Pro↓Tyr-Ser-Ser-Glu-Thr-Thr-OH
4 (IL-1β N terminus)	H-Ala-Pro↓Val-Arg-Ser-Leu-Asn-Cys-Thr-Leu-Arg-Asp-Ser-Asn-Asn-Lys-OH
5	H-Gly-Pro↓Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-OH
6 (IL-1β N terminus)	H-Ala-Pro↓Val-Arg-Ser-Leu-OH
7	H-Leu-Pro↓Asp-Leu-Asp-Ser-Ser-Leu-Ala-Ser-Ile-Gln-Glu-Leu-Leu-Ser-Pro-Gln-Glu-Pro-Pro-Arg-Pro-Pro-Glu-OH
8 (β-casomorphin)	H-Tyr-Pro↓Phe-Pro↓Gly-Pro↓Ile-OH
9 (IL-2 N terminus)	H-Ala-Pro↓Thr-Ser-Ser-Ser-Thr-Lys-Lys-Thr-Arg-OH
10	H-Val-Pro-Pro-Gly-Glu-Asp-Ser-Lys-OH
11	H-Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg-OH
12	H-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
13	H-Pro-Asn-Pro-Asn-Gln-Gly-Asn-Phe-Ile-OH
14	H-Gln-Lys-Gln-Met-Ser-Asp-Arg-Arg-Glu-Asn-Asp-Met-Ser-Pro-Ser-Asn-Asn-Val-Val-Pro-Ile-His-Val-Pro-Pro-Thr-Thr-Glu-Asn-Lys-Pro-Lys-Val-Gln-OH
15	H-Phe-Leu-Arg-Glu-Pro-Val-Ile-Phe-Leu-OH
16	H-Gly-Ile-Arg-Pro-Tyr-Glu-Ile-Leu-Ala-OH
17	H-Cys-Leu-Ser-Ser-Gly-Thr-Leu-Pro-Gly-Pro-Gly-Asn-Asp-Ala-Ser-Arg-Glu-Leu-Glu-Ser-OH
18	H-Trp-Ala↓Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
19	H-Ile-Ala↓Arg-Arg-His-Pro-Tyr-Phe-Leu-OH
20	H-Lys-Ile-Ala-Gly-Tyr-His-Leu-Glu-Leu-OH

^a↓ indicates cleavage site.