Table 1.

Summary of four randomized controlled trials for surveillance colonoscopy comparing HD CE vs. HD WLE in patients with IBD

Study	Country	HD CE	HD WLE	Dysplasia detection rates
Iacucci et al. (2018)35	Canada (single-center)	90 Patients with IBD, targeted biopsy	90 Patients with IBD, targeted biopsy	HD CE vs. HD WLE: 17.8% (16/90)  vs. 18.9% (17/90), p=0.91
Yang et al. (2019)37	Korea (multi-center)	108 Patients with UC, targeted biopsy	102 Patients with UC, random biopsy	HD CE vs. HD WLE: 3.9% (4/102) vs. 5.6% (6/108), p=0.749
Alexandersson et al. (2020)36	Sweden (single-center)	152 Patients with IBD, random biopsy	153 Patients with IBD, random biopsy	HD CE vs. HD WLE: 11.2% (17/152) vs 4.6% (7/153), p=0.032
Wan et al. (2020)34	China (multi-center)	39 Patients with UC, targeted biopsy	43 Patients with UC, targeted biopsy	HD CE vs. HD WLE with targeted biopsy: 9.7% (14/145) vs. 1.9% (3/154), p=0.004
			40 Patients with UC, random biopsy	HD CE vs. HD WLE with random biopsy: 9.7% (14/145) vs. 8.1% (12/148), p=0.642

HD, high-definition; CE, chromoendoscopy; WLE, white-light endoscopy; IBD, inflammatory bowel disease; UC, ulcerative colitis.