Figure 4.

Dose–response association between vigorous physical activity volume (minutes/week) and all-cause, cardiovascular disease, and cancer mortality. Timescale was age. Adjusted for sex, wear time, light intensity, moderate intensity, frequency of vigorous bouts, smoking history, alcohol consumption, sleep score, diet, discretionary screen-time, education, self-reported parental history of CVD and cancer, and self-reported medication use (cholesterol, blood pressure, and diabetes). The range was capped at the 97.5 percentile to minimize the influence of sparse data. Sample = 71 893; events: all-cause = 1,927, cardiovascular disease = 602, cancer = 1150; reference= 2.2 min/week. Linearity: ACM (P < 0.01); CVD (P = 0.42); cancer (P < 0.01). Nadir: ACM [53.6 min/wk; HR = 0.64 (0.54, 0.77)]; cancer [55.4 min/wk; HR = 0.68 (0.52, 0.88)].