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. 2022 Oct 27;43(46):4801–4814. doi: 10.1093/eurheartj/ehac572

Figure 5.

Figure 5

Dose–response association between vigorous physical activity volume (min/week) and incidence of cardiovascular disease (n = 71 049; events = 3730) and cancer (n = 71 070; events = 1315). Timescale was age. Adjusted for sex, wear time, light intensity physical activity, moderate intensity physical activity, frequency of vigorous bouts, smoking history, alcohol consumption, sleep score, diet, screentime, education, self-reported parental history of CVD and cancer, and self-reported medication use (cholesterol, blood pressure, and diabetes). The range was capped at the 97.5 percentile to minimize the influence of sparse data. Cardiovascular disease: n = 71,049, events = 4567. Cancer: n = 71,070, events = 2854. Reference = 2.17 min/week. Linearity: CVD (P < 0.01); cancer (P < 0.01). Nadir: CVD (56.5 min/wk; HR = 0.69 [0.63, 0.76]); cancer (46.3 min/wk; HR = 0.67 [0.55, 0.82]).