Table 2.
Patients in the intermediate and UTI susceptible cohorts by de-escalation status
| Intermediate or UTI Susceptible | ||
|---|---|---|
| Patients not de-escalated to first-generation cephalosporin |
Patients de-escalated to first-generation cephalosporin |
|
| N | 224 | 7 |
| Age, median [IQR] | 72 [58, 80] | 78 [59, 84] |
| Female, n (%) | 173 (77) | 4 (57) |
| Cefazolin MIC, n (%) | ||
| 4 µg/mL | 136 (61) | 5 (71) |
| 8 or 16 µg/mL | 88 (39) | 2 (29) |
| History of cephalosporin allergy, n (%) | 14 (6) | 0 (0) |
| Secondary indication for antibiotics, n (%) | 26 (12) | 1 (14) |
| Admission to intensive care unit, n (%) | 43 (19) | 0 (0) |
| Complicating factors of UTI, n (%) | ||
| Any complicating factor* | 86 (38) | 1 (14) |
| Pyelonephritis | 35 (16) | 0 (0) |
| Kidney stones | 36 (16) | 0 (0) |
| Urinary obstruction | 15 (7) | 0 (0) |
| Neurogenic bladder | 3 (1) | 0 (0) |
| Urologic procedure | 18 (8) | 0 (0) |
| Chronic catheter | 13 (6) | 0 (0) |
| Bacteremia | 32 (14) | 1 (14) |
| Urine culture isolate AST data, n (%) | ||
| Susceptible to fluoroquinolones | 134 (60) | 4 (57) |
| Susceptible to nitrofurantoin | 187 (84) | 5 (71) |
| Susceptible to TMP/SMX | 115 (51) | 2 (29) |
*
Patients could have more than one complicating factor.
ADR = adverse drug reaction, AST = antimicrobial susceptibility testing, IQR = Inter-quartile range.
MIC = minimum inhibitory concentration, TMP/SMX = trimethoprim/sulfamethoxazole, UTI = urinary tract infection.