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. 2022 Jul 11;2(1):e115. doi: 10.1017/ash.2022.251

Table 4.

Interrupted Time-Series Analysis for Hospital-wide Antimicrobial Consumption

Antibiotics Inpatient Outpatient
Trend During Phase 1;
β 1 (95% CI)		 P
Value		 Change
in Level;
β 2 (95% CI)		 P
Value		 Change in Slope Between 2 Phases; β 3 (95% CI) P
Value		 Trend During Phase 1;
β 1 (95% CI)		 P
Value		 Change
in Level;
β 2 (95% CI)		 P
Value		 Change in Slope Between 2 Phases;
β 3 (95% CI)		 P
Value
1GC 0.05
(−0.14 to 0.23)		 .62 −0.17
(−4.76 to 4.42)		 .94 0.50
(−0.16 to 1.15)		 .13 0.44
(0.26 to 0.63)		 <.001 −1.21
(−5.83 to 3.41)		 .60 0.30
(−0.36 to 0.95)		 .36
Fluoroquinolones 0.32
(−0.05 to 0.68)		 .091 1.98
(−7.3 to 11.25)		 .67 −0.59
(−1.91 to 0.73)		 .37 0.23
(−0.01 to 0.46)		 .058 0.09
(−5.79 to 5.96)		 .98 0.40
(−0.43 to 1.24)		 .33
Macrolides 0.22
(0.01 to 0.43)		 .037 −2.42
(−7.63 to 2.79)		 .35 −0.12
(−0.86 to 0.62)		 .73 0.66
(−0.06 to 1.38)		 .073 −7.70
(−25.86 to 10.46)		 .39 0.26
(−2.32 to 2.84)		 .84
Penicillins 0.04
(−0.2 to 0.28)		 .76 5.79
(−0.28 to 11.86)		 .061 −0.47
(−1.33 to 0.39)		 .28 0.49
(0.17 to 0.82)		 .004 6.25
(−1.97 to 14.47)		 .13 0.62
(−0.55 to 1.79)		 .29
IV antibiotics 0.10
(0.04 to 0.16		 .002 0.93
(−0.55 to 2.41)		 .21 −0.22
(−0.43 to −0.01)		 .044 … … … … … …

Note. 1GC, first-generation cephalosporins; CI, confidence interval; IV, intravenous.