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. 2022 May 19;20(6):465–474. doi: 10.2450/2022.0013-22

Table I.

Pathway of TRALI tested and employed insults

TRALI Pathway 1st hit 2nd hit
Neutrophil-independent pathway (Bayat et al. 201312)
One-hit model Media (control)
Control serum
Anti-HNA-3a serum #1
Anti-HNA-3a serum #2		 N/A
Two-hit model LPS Media (control)
Control serum
Anti-HNA-3a serum #1
Anti-HNA-3a serum #2
Neutrophil-dependent pathway (Silliman et al. 200710)
One-hit model Media (control)
PMA (control)
Control serum
Anti-HNA-3a serum #1
Anti-HNA-3a serum #2		 N/A
Two-hit model LPS Media (control)
PMA (control)
Control serum
Anti-HNA-3a serum #1
Anti-HNA-3a serum #2

LPS: lipopolysaccharide; HNA: human neutrophil antigen; PMA: phorbol 12-myristate 13-acetate; TRALI: transfusion-related acute lung injury.