Table I.
Demographics and clinical characteristics of TRALI and possible TRALI cases between 1999 and 2019
| Characteristics | TRALI | Possible TRALI | All categories | |
|---|---|---|---|---|
|
| ||||
| Number | 30 | 18 | 48 | |
|
| ||||
| Sex | • Males | 15 (50.0%) | 11 (61.1%) | 26 (54.2%) |
| • Females | 15 (50.0%) | 7 (38.9%) | 22 (45.8%) | |
| • Sex ratio M/F | 1.0 | 1.6 | 1.2 | |
|
| ||||
| Age (years) | • Mean | 47.1 | 48.5 | 47.6 |
| • Median | 46.5 | 47.5 | 47.5 | |
| • Range | 4–84 | 2–87 | 2–87 | |
|
| ||||
| Hospital Location | • Metropolitan | 16 (53.3%) | 8 (44.4%) | 24 (50.0%) |
| • Rural/Regional | 14 (46.7%) | 10 (55.5%) | 24 (50.0%) | |
|
| ||||
| Fatalities | 0 (0%) | 2 (11.1%) | 2 (4.2%) a | |
|
| ||||
| Primary clinical condition | • Haematological malignancy | 8 (26.7%) | 4 (22.2%) | 12 (25.0%) |
| • Surgery | 2 (6.7%) | 5 (27.8%) | 7 (14.6%) | |
| • Liver disease | 4 (13.3%) | 2 (11.1%) | 6 (12.5%) | |
| • Non-haematological malignancy | 4 (13.3%) | 1 (5.6%) | 5 (10.4%) | |
| • Aplasia/MDS | 3 (10.0%) | 1 (5.6%) | 4 (8.3%) | |
| • Trauma | 3 (10.0%) | 1 (5.6%) | 4 (8.3% | |
| • Immunological disorder | 2 (6.7%) | 0 (0.0%) | 2 (4.2%) | |
| • Other | 4 (13.3%) | 4 (22.2%) | 8 (16.7%) | |
|
| ||||
| ALI risk factors | • Shock | 5 (27.8%) | ||
| • Pneumonia | 5 (27.8%) | |||
| • Sepsis | 4 (22.2%) | |||
| • Cardiopulmonary bypass | 3 (16.7%) | |||
| • Multi-trauma | 1 (5.6%) | |||
|
| ||||
| Timing of onset (hr) | • <1 hr post | 26 (86.7%) | 10 (55.6%) | 36 (75.0%) |
| • 1–3 hrs post | 2 (6.7%) | 4 (22.2%) | 6 (12.5%) | |
| • 3–6 hrs post | 2 (6.7%) | 4 (22.2%) | 6 (12.5%) | |
|
| ||||
| Clinical features | • Evidence of hypoxia and/or respiratory distress b | 30 (100%) | 18 (100%) | 48 (100%) |
| • Chestradiological findings | 30 (100%) | 18 (100%) | 48 (100%) | |
|
| ||||
| Admitted to ICU c | 6 (20.0%) | 6 (33.3%) | 12 (25.0%) | |
|
| ||||
| Treatment | • Oxygen | 26 (86.7%) | 17 (94.4%) | 43 (89.6%) |
| • Furosemide | 13 (43.3%) | 6 (33.3%) | 19 (39.6%) | |
| • Respiratory support | 9 (30.0%) | 7 (38.9%) | 16 (33.3%) | |
| • Steroids | 7 (23.3%) | 2 (11.1%) | 9 (18.8%) | |
| • Other | 6 (20.0%) | 6 (33.3%) | 12 (25.0%) | |
| • Treatment not stated | 1 (3.3%) | 1 (5.6%) | 2 (4.2%) | |
|
| ||||
| Severity | • Mild | 15 (50.0%) | 4 (22.2%) | 19 (39.6%) |
| • Severe | 5 (16.7%) | 4 (22.2%) | 9 (18.8%) | |
| • Life threatening/Death | 10 (33.3%) | 10 (55.6%) | 20 (41.7%) | |
a
excludes fatality events unrelated to TRALI;
b
Hypoxia presenting with either low oxygen saturations or need for oxygen/ntilator support;
c
Admitted to ICU at time of reporting.