Table II.
Correlations between direct oral anticoagulant concentration and calibrated automated thrombogram parameters
| Drug concentration | DOAC | Lag-time | Peak | ETP | Velocity | |
|
| ||||||
| Dabigatran (n=62) | rho | 0.681 | −0.373 | −0.627 | −0.181 | |
| p | <0.0001 | 0.0076 | <0.0001 | 0.21 | ||
|
| ||||||
| Apixaban (n=76) | rho | 0.790 | −0.741 | −0.149 | −0.631 | |
| p | <0.0001 | <0.0001 | 0.21 | <0.0001 | ||
|
| ||||||
| Edoxaban (n=58) | rho | 0.843 | −0.921 | −0.126 | −0.931 | |
| p | <0.0001 | <0.0001 | 0.40 | <0.0001 | ||
|
| ||||||
| Rivaroxaban (n=78) | rho | 0.732 | −0.773 | −0.506 | −0.777 | |
| p | <0.0001 | <0.0001 | <0.0001 | <0.0001 | ||
Rank correlation analysis was performed by combining C-Trough and C-Peak samples. ETP: endogenous thrombin potential; rho, Spearman’s correlation coefficient; DOAC: direct oral anticoagulant.