Table 3.

Comparison of the laboratory data before and after vaccination.^†

	Before vaccination	After vaccination‡	Change of value	P value§
1st vaccination
Total bilirubin – mg/dl	0.6 [0.5, 0.9]	0.6 [0.4, 0.8]	0.0 [−0.2, 0.0]	0.15
Aspartate aminotransferase – IU/l	20 [16, 23]	19 [17, 21]	0.0 [−1.5, 1.0]	0.57
Alanine aminotransferase – IU/l	15 [12, 20]	14 [11, 19]	−1 [−3, 1]	0.046
γ-Glutamyl transpeptidase – IU/l	16 [14, 25]	16 [13, 28]	−1 [−3, 0]	0.01
Serum creatinine – mg/dl	0.63 [0.57, 0.70]	0.62 [0.56, 0.69]	0.00 [−0.03, 0.05]	0.46
eGFR‖ – ml/min/m2	89.2 [78.6, 99.9]	91.3 [76.0, 97.4]	0.0 [−6.3, 5.1]	0.57
2nd vaccination
Total bilirubin – mg/dl	0.6 [0.4, 0.8]	0.6 [0.5, 0.8]	0.0 [−0.1, 0.1]	0.25
Aspartate aminotransferase – IU/l	19 [17, 21]	18 [16, 21]	0 [−2, 1]	0.43
Alanine aminotransferase – IU/l	14 [11, 19]	14 [11, 19]	0 [−2, 2]	0.94
γ-Glutamyl transpeptidase – IU/l	16 [13, 28]	17 [13, 28]	0 [−1, 1]	0.93
Serum creatinine – mg/dl	0.62 [0.56, 0.69]	0.61 [0.55, 0.68]	0.00 [−0.05, 0.02]	0.41
eGFR‖ – ml/min/m2	91.3 [76.0, 97.4]	90.4 [74.7, 101.1]	0.0 [−3.5, 6.1]	0.43
3rd vaccination
Total bilirubin – mg/dl	0.6 [0.5, 0.8]	0.6 [0.5, 0.8]	0.0 [−0.1, 0.1]	0.46
Aspartate aminotransferase – IU/l	18 [16, 21]	19 [17, 22]	0 [−2, 2]	0.30
Alanine aminotransferase – IU/l	14 [11, 19]	16 [11, 21]	0 [−1, 2]	0.47
γ-Glutamyl transpeptidase – IU/l	15 [13, 20]	16 [14, 23]	0 [−1, 2]	0.10
Serum creatinine – mg/dl	0.62 [0.57, 0.69]	0.62 [0.55, 0.70]	0.00 [−0.04, 0.03]	0.50
eGFR‖ – ml/min/m2	90.4 [80.8, 98.1]	89.2 [74.8, 101.3]	0.0 [−3.8, 6.9]	0.44

eGFR, estimated glomerular filtration rate.

^†Data are shown as the median [1st quartile, 3rd quartile].

^‡Blood samples were collected three weeks after the 1st vaccination (just before the 2nd vaccination) and one month after the 2nd and 3rd vaccinations.

^§P values were calculated using the Wilcoxon signed-rank sum test.

^‖The parameter was calculated using the following equation: 194 ∗ serum creatinine^−1.094 ∗ age^−0.287 (∗ 0.739 [if female]).