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. 2022 Dec 7;26(1):105753. doi: 10.1016/j.isci.2022.105753

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© 2022 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Functional antibody responses correlate with antibody binding to the ancestral SARS-CoV-2 S protein

(A) Correlation between S1-specific binding antibodies measured by Liaison and S-specific binding antibodies measured by ELISA.

(B) Correlation between neutralizing antibodies and S-specific binding antibodies measured by ELISA

(C) Correlation between NK cell degranulation mediating S-specific antibodies (ADCC) and S-specific antibody binding measured by ELISA.

(D) Correlation between phagocytosis-mediating antibody titers (ADCP) and S-specific binding antibodies as measured by ELISA. Colors represent different booster groups: no boost (grey), Ad26.COV2.S boost (red), mRNA-1273 boost (green), and BNT162b2 boost (blue). Symbols represent individual donors post-booster vaccination (n = 15 per group). Simple linear regression analysis on log-transformed data was used to calculate Spearman’s correlation coefficient and p-values.