TABLE 1.
Incidence of side effects observed during the 21 days after ingestion of high-dose vaccine, lower-dose vaccine, or buffer placebo
| Symptom or sign | No. (%) of recipients in the following group:
|
P valuea for placebo vs the following vaccine:
|
|||
|---|---|---|---|---|---|
| Placebo | Vaccine
|
Lower dose | High dose | ||
| Lower dose | High dose | ||||
| Malaise | 22 (29) | 10 (26) | 12 (31) | 0.83 | 0.83 |
| Anorexia | 13 (17) | 6 (15) | 9 (23) | 1.00 | 0.46 |
| Headache | 30 (39) | 13 (33) | 18 (46) | 0.55 | 0.55 |
| Cramps | 18 (24) | 13 (33) | 12 (31) | 0.28 | 0.50 |
| Nausea | 15 (20) | 8 (21) | 5 (13) | 1.00 | 0.44 |
| Vomiting | 3 (4) | 3 (8) | 1 (3) | 0.33 | 0.58 |
| Fever | 2 (3) | 1 (3) | 0 (0) | 1.00 | 0.55 |
| Diarrhea | 3 (4) | 1 (3) | 4 (10) | 0.58 | 0.18 |
a
Determined with one-tailed Fisher's exact test.