TABLE 1.

Application of brain organoids: diseases modelling and drug screening.

Application	Gene	References
ASD	FOXG1	Mariani et al. (2015)
ASD	DISC1	Qian et al. (2020)
ASD	CHD8	Wang et al. (2017)
ASD	RAB39B	Zhang et al. (2020)
AD	APP, PS1	Choi et al. (2014)
AD	—	Lee et al. (2016); Park et al. (2018)
AD	APOE4	Zhao et al. (2020)
GBM	—	Hubert et al. (2016; Jacob et al. (2020); Ogawa et al. (2018); da Silva et al. (2018)
Sandhoff	—	Allende et al. (2018)
FXS	FMR1	Brighi et al. (2021)
Lissencephaly		Bershteyn et al. (2017); Iefremova et al. (2017)
MCPH	CDK5RAP2	Lancaster et al. (2013)
ZIKV-induced microcephaly		Cugola et al. (2016); Dang et al. (2016); Garcez et al. (2016); Qian et al. (2016); Sutarjono, (2019)
Schizophrenia	15q11.2 copy number microdeletion	Yoon et al. (2014)
Schizophrenia	DISC1	Ye et al. (2017)
Drug screening		Phan et al. (2017); Dang et al. (2021)