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. 2022 Nov 23;13:957148. doi: 10.3389/fmicb.2022.957148

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Copyright © 2022 Abraham, Chan, Zhou and Seah.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo effects of aflatoxin B1 and microbial detoxification approaches. (A) Aflatoxin B1, produced by members of Aspergillus is carcinogenic, genotoxic, and possesses immunosuppressive properties. (B) Bacillus licheniformis ANSB821 utilizes the laccase, CotA to biotransform aflatoxin B1. (C) The manganese peroxidase MnP from the white-rot fungus Phanerochaete sordida YK-624 oxidizes AFB1 to form AFB1-8,9-dihydrodiol via an 8,9-epoxide intermediate. (D) Proposed reduction of AFB1 ring by a deazaflavin cofactor (F₄₂₀) containing M. smegmatis enzyme.