TABLE 3.

Positive Epigenetic Age Acceleration (EAA) is evident in men from the Blue Zone relative to women from the Blue Zone. The coefficient estimate indicates the linear model β coefficient associated with the specified independent variable in brackets, and Cohen’s f ² effect size based on the Adjusted R ² of the linear model. Bolded p-values indicate significance (corrected p-value < 0.00556).

	Coefficient estimate β (men)	Multiple R 2	Adjusted R 2	Cohen’s f 2	p-value
Horvath EAA	1.07	0.195	0.139	0.161	0.00378
Hannum EAA	1.42	0.171	0.114	0.129	0.0103
PhenoAge EAA	1.30	0.177	0.120	0.137	0.00810
GrimAge EAA	3.55	0.533	0.501	1.00	1.22 × 10 −12
Skin and Blood EAA	0.249	0.0147	−0.0531	−0.0504	0.970
Pace of Aging	0.0344	0.429	0.383	0.620	1.77 × 10 −08
DNAmTL	−0.0443	0.346	0.301	0.430	1.28 × 10 −06
Smoking Score	1.00	0.103	0.0410	0.0428	0.140
Serum IL-6	−0.00301	0.524	0.491	0.964	2.84 × 10 −12