Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 23;13:1016304. doi: 10.3389/fimmu.2022.1016304

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Mortezaee and Majidpoor

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Different orchestration of cells of the immune system within the blood or lung of patients with severe SARS-CoV-2-induced disease. Monocyte-derived DCs (mDCs), non-classical monocytes, T helper 1 (Th1) cells, and myeloid-derived suppressor cells (MDSCs) are high in the peripheral blood of patients with severe disease. By contrast, CD8⁺ T cells, plasmacytoid DCs (pDCs), CD1c⁺ DCs, natural killer (NK) cells, macrophage type 2 (M2) cells, and regulatory T cells (Tregs) show low fraction within the circulation. M1 macrophages are high, whereas M2 macrophages are low within the lung of severe cases.