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The impact of severe SARS-Cov2 induced disease on cellular immunity. In patients with a severe disease the activity of regulatory T cell (Tregs) and M2 macrophage is hampered. Whereas M1 macrophage, myeloid-derived suppressor cells (MDSCs), monocytes, neutrophils and Th1 cells show increased expansion. Other consequences of a severe infection are plasmacytoid dendritic cell (pDC) apoptosis, and CD8+ T cell and natural killer (NK) cell exhaustion.
