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. 2021 Apr 14;17(1-2):195–205. doi: 10.1007/s11481-021-09994-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — 2CdA treatment reduces T- and B-cell viability. Flow cytometry analysis of viability of (a) CD4 + T cells and (b) CD19 + B cells treated as indicated for 48 and 72 h, using Annexin V/propidium iodide labeling of apoptotic cells and necrotic cells, respectively. Data are presented for cells from 8 (CD4 + T cells) or 5 (CD19 + B cells) healthy donors assayed in independent experiments; * P < 0.05, ** P < 0.01, **** P < 0.0001. Unstim. = unstimulated cells; Unstim. + 2CdA = unstimulated cells treated with 2CdA (500 nM); Stim. = cells stimulated with anti-CD3/CD28 beads (CD4 + T cells) or IL-15/CpG (CD19 + B cells); Stim. + 2CdA = cells (CD4 + T cells or CD19 + B cells) stimulated as before and treated with 2CdA (500 nM)