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. 2022 Sep 29;30(1):233–243. doi: 10.1245/s10434-022-12355-w

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Analysis of the diagnostic index using the combinations and panel of miRNAs. a ROC curves for the combination of five miRNAs (miR-25-3p, miR-1246, miR-1268b, miR-4648, and miR-6131). b ROC curves for the combination of four miRNAs (miR-25-3p, miR-1246, miR-1268b, and miR-4648). c ROC curves for the combination of three miRNAs (miR-1246, miR-1268b and miR-4648). d Comparison of each combination, CEA, and CA19-9. e The cut-off line of the combination of three miRNAs in three dimensions: blue indicates no cancer; red indicates cancer. miRNAs microRNAs, ROC receiver operating characteristic, CA19-9 carbohydrate antigen 19-9